4 edition of Structure-activity relationships in human chemoreception found in the catalog.
Structure-activity relationships in human chemoreception
M. G. J. Beets
by Applied Science in London
|Statement||M. G. J. Beets.|
|LC Classifications||QP455 .B43|
|The Physical Object|
|Pagination||xii, 408 p. :|
|Number of Pages||408|
|LC Control Number||78324346|
A QSAR is a mathematical model that quantitatively relates a quantitative numerical measure of chemical structure (e.g., a physico-chemical property) to a physical property or to a biological effect (e.g., a toxicological endpoint). The fields of his research interest are Quantitative Structure-Activity Relationship (QSAR) and Chemometric Modeling with application in Drug Design and Ecotoxicological Modeling. Dr. Roy has published about research articles in refereed journals (current SCOPUS h index 40; SCOPUS Author ID ).Brand: Springer US.
Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships. Structure Activity Relationships (SAR) can be used to predict biological activity from molecular structure. This powerful technology is used in drug discovery to guide the acquisition or synthesis of desirable new compounds, as well as to further characterize existing molecules.
Molecules, an international, peer-reviewed Open Access journal. Dear Colleagues, We are pleased to host a Special Issue in the journal Molecules (IF: ) on “Structure–Activity Relationships (SAR) of Natural Products (NPs)” in drug discovery. This topic has recently drawn a lot of attention and there is increasing interest in NPs as a “source of inspiration” for the discovery of. A lack of selectivity of classical agonists for the nicotinic acetylcholine receptors (nAChR) has prompted us to identify and develop a distinct scaffold of α7 nAChR-selective ligands. Noncanonical 2,4,6-substituted pyrimidine analogues were framed around compound 40 for a structure–activity relationship study. The new lead compounds activate selectively the α7 nAChRs with EC50’s between Author: Gisela Andrea Camacho-Hernandez, Clare Stokes, Brendan M. Duggan, Katarzyna Kaczanowska, Stefania Br.
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Pathways during odour petX;elmon structural features of odorant molecules and the last is devoted to a theory of the primary olfaction process.
Some general aspects of chemoreception Chemoreception covers the whole field of effects resulting from stimulation of the senses of Cited by: RESEARCH PAPER Structure-activity relationships of pentamidine-affected ion channel trafﬁcking and dofetilide mediated rescue R Varkevisser1,MJCHoutman1, T Linder2,KCGdeGit1, H D M Beekman1,RRTidwell3, A P IJzerman4, A Stary-Weinzinger2, MAVos1 andMAGvanderHeyden1 1Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands,Cited by: The dicaffeoylquinic acids (DCQAs) and dicaffeoyltartaric acids (DCTAs) are potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase.
They also inhibit HIV-1 replication at nontoxic concentrations. Since integrase is an excellent target for anti-HIV therapy, structure−activity relationships were employed to synthesize compounds with: (1) improved potency Cited by: Book review Full text access Structure-activity relationships in human chemoreception: By M.
Beets. Applied Science Publishers Ltd, London. xii × pp. Price: £25 The novel approach to structure-activity relationships therefore lies in the determination of solution properties as measurements of the effective size, shape and probable functional activities of sapid molecules in a medium of by: Structure–activity relationships on the odor detectability of homologous carboxylic acids by humans J.
Enrique Cometto-Muñiz 1 and Michael H. Abraham 2 1 Chemosensory Perception Laboratory, Department of Surgery (Otolaryngology), University of California, San Diego, Gilman Dr., Mail CodeLa Jolla, CA USACited by: However, although such maps do offer visual cues to structure-activity relationships, they rarely provide quantitative relationship between structural descriptors and activity.
At the present time, artificial neural networks (ANN) are probably the most widely used non-linear methods in chemometric and QSAR applications (see Chapter 1).Cited by: 1. In the search for improved selective antagonist ligands of the A2B adenosine receptor, which have the potential as antiasthmatic or antidiabetic drugs, we have synthesized and screened a variety of alkylxanthine derivatives substituted at the 1- 3- 7- and 8-positions.
Competition for I-ABOPX (I(4-aminoiodobenzyl)(phenyloxyacetate)propylxanthine) binding in Cited by: Structure-Activity Relationships in Environmental Science is the first book of its kind that brings together information from a variety of sources into one document.
It provides a comprehensive overview of the entire field of quantitative structure-activity relationships (QSARs) as. Structure-activity relationships. Oxford, New York, Pergamon Press [(OCoLC) Online version: Structure-activity relationships. Oxford, New York, Pergamon Press [(OCoLC) Document Type: Book: All Authors / Contributors: M G J Beets.
Structure-activity relationships of insect defensins. The variety of insect AMPs is also reflected within their secondary and tertiary structures. They can be broadly divided into three major groups, i.e., (i) primarily α-helical peptides, (ii) peptides rich in one particular amino acid (e.g., proline or glycine) and (iii) cysteine-rich by: Structure—activity relationships in chemoreception by human olfaction Previous Article The so-called leucocidins Next Article Trace biogenic amines: a possible functional role in the CNSCited by: Structure-activity relationships in human chemoreception.
London: Applied Science, (OCoLC) Document Type: Book: All Authors / Contributors: M G J Beets. Processes Underlying Interactions of Human Lactoferrin with the Jurkat Human Lymphoblastic T‐cell Line Receptor. I ‐ Quantitative Structure‐Affinity Relationships Studies Abdelaziz Elass.
Author(s): Beets,M G J Title(s): Structure-activity relationships in human chemoreception/ M. Beets. Country of Publication: England Publisher: London. Get this from a library. Structure-activity relationships in chemoreception: proceedings of a symposium.
[G Benz; European Chemoreception Research Organization. Symposium]. The affinity between thymol and human OR1G1 was assessed by calcium imaging experiments on cells expressing the receptor. Then, a model of human OR1G1 was built on the basis of a sequence alignment performed with respect to other class A : Jérôme Golebiowski, Landry Charlier, Jérémie Topin, Sébastien Fiorucci, Serge Antonczak.
Learn why some drug discovery and development efforts succeed and others fail. Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples.
Investigations of structure activity relationships will be abbreviated to SAR studies. This notation is vague because it is also frequently used for structure action relationship studies. The action, or effect, of a drug is a qualitative phenomenon while its activity is a Cited by: Die Wahrnehmungsschwellenwerte und Geruchsqualitäten von Verbindungen, wie Alkohole, Aldehyde, Ketone, Carbonsäuren und Ester, die überwiegend homologen Reihen angehören, wurden in Wasser ermittelt, davon zum ersten Mal.
Die Abhängigkeit des Schwellenwertes von Strukturparametern wie Art, Anzahl und Position funktioneller Gruppen, Länge der Alkylketten sowie Cited by:. Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse.
There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available.
In this volume, leading.In a first section we will try to understand the organization of chemoreception from the chemical-structure/sensation relationship. In a second section we will briefly touch on the biochemical evidence for olfactory and taste receptors. In the last section we will study a family of proteins that are models for olfactory : E.
Bignetti, A. Cavaggioni, R. Tirindelli.Structure–Activity Relationships for Development of Neurokinin-3 Receptor Antagonists Yamamoto, K. () This book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact.